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Nebil Attia

 

Nebil Attia

National Institute of Nutrition, Tunisia

Abstract Title:

Polymorphism of Abca1 (I883m) is Associated to Lipid Profile Alteration in Cad Patients Without Type 2 Diabetes

Biography:

A professor of biochemistry and nutrition since 1998, Nebil ATTIA is a graduate of the University of Paris 7, now known as Université Paris-Cité. His research focuses on investigating alterations in lipid metabolism and its regulatory factors, particularly in type 2 diabetes, obesity, and coronary artery diseases. His work has resulted in dozens of national and international publications in high-impact scientific journals. Professor ATTIA is also an expert in the field of lipoprotein metabolism and its regulation, as well as in nutritional diseases, including dietary deficiencies. He has also conducted research on bone metabolism and metabolic syndrome. He was a founding member and treasurer of the Tunisian Association for the Study and Research of Atherosclerosis (ATERA) His university teaching in University of Carthage, Tunisia focuses on biochemistry and its various aspects, as well as human nutrition, covering both its fundamental and pathological aspects. At the same university, he was the chair of the Department of Life Sciences. In addition, Professor ATTIA has supervised a significant number of doctoral students (PhD), master’s students, and students working on research grants. Since 2025, he has served as Head of the “Research and Planning” Department at the National Institute of Nutrition in Tunis, Tunisia.

Research Interests:

1Surven-Tunisie Lab (LR12SP05), National Institute of Nutrition and Food Technology (INNTA), El Manar University, Tunis, Tunisia, 2Department of Cardiology, Hospital of Menzel Bourguiba, Tunisia, 3Integrated Physiology Lab (LRM17ES02), Sciences Faculty of Bizerte, Carthage University, Bizerte, Tunisia, 4Integrated Physiology Lab (LRM17ES02), Sciences Faculty of Bizerte, Carthage University, Bizerte, Tunisia, 5Lab of genetic and immunology, Faculty of Sciences, El Manar University, Tunis, Tunisia. Background and Aims: Cardiovascular diseases, in particular acute coronary syndrome, are the leading cause of death and the rate of hospitalizations. Estimating cardiovascular risk is an important step to initiate primary prevention of this disease. We studied the influence of I883M variant of the ATP Binding Cassette A1 (ABCA1) gene, which plays a key role in the reverse transport of cholesterol on clinical and lipid parameters in patients with coronary artery disease (CAD) with or without type 2 disease (T2D). Methods: Three hundred seventy-eight subjects (378) were recruited (95 control, 62 CAD, 58 T2D and 163 CAD+T2D). All were genotyped by PCR-RFLP with EcorV. Clinical and biochemical parameters were performed using conventional methods. Results: Three genotypes of ABCA-1 were detected: GG mutated homozygote, AG mutated heterozygote and AA, the wild genotype. Results show that the GG genotype was associated to CAD (with or without T2D). AG genotype was associated to hypertriglyceridemia only in T2D group. However, GG genotype was associated to an elevated plasma LDL-C only in CAD group (without T2D) as well as in whole population (n = 378). Conclusions: Our data show that CAD patients with GG genotype are sensitive to develop acute coronary syndrome, probably in association to elevated plasma LDL-C, but independently of type 2 diabetes.